Analytical Data
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Gene name
KIR3DL2
- Application
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Alternative Names
KIR3DL2；HLA-5.4；HLAF；HLA class I histocompatibility antigen. alpha chain F
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P43630
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Expression Region
22-340aa
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AA Sequence
ADPLMGGQDKPFLSARPSTVVPRGGHVALQCHYRRGFNNFMLYKEDRSHV PIFHGRIFQESFIMGPVTPAHAGTYRCRGSRPHSLTGWSAPSNPLVIMVT GNHRKPSLLAHPGPLLKSGETVILQCWSDVMFEHFFLHREGISEDPSRLV GQIHDGVSKANFSIGPLMPVLAGTYRCYGSVPHSPYQLSAPSDPLDIVIT GLYEKPSLSAQPGPTVQAGENVTLSCSSWSSYDIYHLSREGEAHERRLRA VPKVNRTFQADFPLGPATHGGTYRCFGSFRALPCVWSNSSDPLLVSVTGN PSSSWPSPTEPSSKSGICRHLHVEPKSCDKTHTCPPCPAPELLGGPSVFL FPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPR EEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQ PREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYK TTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLS LSPGKHHHHHH
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Molecular Weight
62 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIR3DL2 is a member of the killer immunoglobulin-like receptor (KIR) family, which plays a crucial role in the regulation of natural killer (NK) cell functions and the immune response. It is primarily expressed on NK cells and some T cells, where it interacts with its ligand, HLA-A*24, to modulate cytotoxic activity and cytokine production. Research on KIR3DL2 is significant due to its association with various diseases, including viral infections and certain cancers, where its expression can influence immune evasion and tumor progression. The molecular mechanisms by which KIR3DL2 mediates these effects are not fully understood, highlighting the need for in-depth studies. Recombinant KIR3DL2 protein production provides a valuable tool for studying its structure-function relationships and signaling pathways in immune cells. By utilizing recombinant technology, researchers can generate sufficient quantities of the protein for functional assays, allowing for the exploration of its role in immune modulation. Additionally, understanding the interactions between KIR3DL2 and its ligands can offer insights into potential therapeutic strategies aimed at enhancing anti-tumor immunity or improving responses to viral infections. Overall, the study of KIR3DL2 recombinant protein presents a promising avenue for elucidating its biological functions and potential applications in immunotherapy.
