Analytical Data
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基因名
CTSB
- Application
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别名
CTSB；CPSB;Cathepsin B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P07858
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表达区间
82-333aa
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氨基酸序列
ASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTD
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分子量
27.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CTSB, or Cathepsin B, is a lysosomal cysteine protease that plays a crucial role in various physiological and pathological processes, including protein turnover, antigen processing, and the progression of cancer. Recent studies have highlighted its involvement in tumor invasion and metastasis, making it a potential target for therapeutic interventions. The interest in recombinant CTSB arises from the need to better understand its enzymatic mechanisms and functional implications in cellular environments. By producing recombinant CTSB, researchers can analyze its substrate specificity, develop inhibitors, and explore its interactions with other cellular proteins. This research is pivotal not only for advancing our understanding of CTSB's biological roles but also for paving the way for novel cancer therapies. Moreover, recombinant proteins offer advantages in terms of purity and availability, which facilitates various experimental approaches. Overall, the study of recombinant CTSB is significant for elucidating its contributions to disease pathology and developing strategies to manipulate its activity for therapeutic purposes.
