Analytical Data
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基因名
KIR2DL5
- Application
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别名
KIR2DL5；CD158F；CD158F1；KIR2DL5；Killer cell immunoglobulin-like receptor 2DL5A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8NHK3
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表达区间
1-375aa
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氨基酸序列
MSLMVVSMACVGFFLLQGAWTHEGGQDKPLLSAWPSAVVPRGGHVTLLCRSRLGFTIFSLYKEDGVPVPELYNKIFWKSILMGPVTPAHAGTYRCRGSHPRSPIEWSAPSNPLVIVVTGLFGKPSLSAQPGPTVRTGENVTLSCSSRSSFDMYHLSREGRAHEPRLPAVPSVDGTFQADFPLGPATHGGTYTCFSSLHDSPYEWSDPSDPLLVSVTGNSSSSSSSPTEPSSKTGIRRHLHILIGTSVAIILFIILFFFLLHCCCSNKKNAAVMDQEPAGDRTVNREDSDDQDPQEVTYAQLDHCVFTQTKITSPSQRPKTPPTDTTMYMELPNAKPRSLSPAHKHHSQALRGSSRETTALSQNRVASSHVPAAGI
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分子量
40.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KIR2DL5 is a member of the killer immunoglobulin-like receptor (KIR) family, which plays a crucial role in the regulation of the immune response, particularly in the recognition of self and non-self cells by natural killer (NK) cells. As a receptor found on the surface of NK cells, KIR2DL5 is known to interact with specific molecules on target cells, influencing immune surveillance and responses to infections and tumor cells. This receptor is unique due to its capability to recognize diverse HLA class I molecules, which are pivotal for distinguishing healthy cells from those that are infected or transformed. The study of recombinant KIR2DL5 protein has gained significance in immunology and therapeutic research, as understanding its structure and function can provide insights into its role in immune regulation. Additionally, KIR2DL5 has been implicated in various diseases, including autoimmune disorders and cancers, making it a potential target for novel immunotherapeutic strategies. Researchers focus on producing recombinant KIR2DL5 to explore its binding affinities, signal transduction pathways, and potential therapeutic applications, ultimately aiming to harness its properties for enhancing immune responses against malignancies and infectious diseases. The recombinant form of the protein is also pivotal for the development of diagnostic tools and vaccine strategies, underscoring the importance of KIR2DL5 in modern immunological research.
