Analytical Data
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Gene name
CSNK2A1
- Application
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Alternative Names
CSNK2A1；CK2A1;Casein kinase II subunit alpha
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P68400
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Expression Region
1-391aa
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AA Sequence
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ
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Molecular Weight
52.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSNK2A1, also known as Casein Kinase 2 alpha 1, is a serine/threonine protein kinase that plays a crucial role in various cellular processes, including cell proliferation, differentiation, and apoptosis. Dysregulation of CSNK2A1 has been implicated in several diseases, particularly cancer, making it a significant target for research. The enzyme is known to modulate multiple signaling pathways and interacts with several substrates, contributing to its essential role in cellular homeostasis. Research involving recombinant CSNK2A1 proteins has advanced our understanding of its biochemical properties, substrate specificity, and regulatory mechanisms. Specifically, the study of its enzymatic activity and interaction with inhibitors provides valuable insights into the potential development of targeted therapies. Furthermore, recombinant expression systems have enabled the production of the kinase in sufficient quantities for structural and functional studies, aiding in the elucidation of its role in various pathophysiological states and contributing to the identification of novel therapeutic approaches. Overall, the study of recombinant CSNK2A1 is pivotal for understanding its role in health and disease, and may pave the way for innovative cancer treatments and other therapeutic strategies.
