Analytical Data
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基因名
LATS1
- Application
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别名
(Large tumor suppressor homolog 1)(WARTS protein kinase)(h-warts)
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种属
Human
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表达系统
E. coli
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标签
N- His & C- Myc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95835
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表达区间
705-1090aa
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分子量
49.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LATS1 (Lateral Sensing Protein 1) is a crucial tumor suppressor protein that plays a significant role in the Hippo signaling pathway, which is essential for regulating cell proliferation, apoptosis, and organ size maintenance. Dysregulation of the Hippo pathway, often due to mutations or aberrant expression of its components, has been linked to various cancers, making LATS1 a protein of considerable interest in cancer research. The recombinant expression of LATS1 provides a powerful tool for studying its biological functions and interaction with other signaling molecules. Researchers utilize recombinant LATS1 proteins to investigate its role in inhibiting cell growth and promoting apoptosis in cancer cells. Additionally, understanding LATS1's structure and function can reveal insights into its mechanisms of action and potential therapeutic applications, as restoring its activity may counteract tumorigenesis. Furthermore, LATS1's involvement in regulating stem cell behavior and tissue regeneration adds another layer of significance to its study. Consequently, the production and characterization of recombinant LATS1 proteins are vital for advancing our knowledge of cancer biology and developing potential strategies for therapeutic intervention.
