Analytical Data
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Gene name
CSNK1D
- Application
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Alternative Names
CSNK1D；HCKID;Casein kinase I isoform delta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P48730
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Expression Region
1-415aa
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AA Sequence
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
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Molecular Weight
54.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSNK1D (casein kinase 1 delta) is a serine/threonine protein kinase that plays a pivotal role in various cellular processes, including circadian rhythm regulation, cell signaling, and protein phosphorylation. Its involvement in the circadian clock highlights its significance in maintaining physiological homeostasis and cellular functions aligned with day-night cycles. Dysregulation of CSNK1D has been linked to various disorders, including sleep disorders, cancer, and metabolic syndromes, prompting significant interest in understanding its mechanisms and potential as a therapeutic target. Research on CSNK1D recombinant proteins has gained traction as these proteins facilitate the elucidation of CSNK1D’s biological roles and interactions at a molecular level. Studies utilizing these recombinant proteins allow for detailed investigations of their enzymatic activity, substrate specificity, and structural dynamics, providing insights into how mutations or aberrant expression of CSNK1D might contribute to disease pathology. Moreover, the development of CSNK1D inhibitors and modulators represents a promising avenue for drug development, particularly in conditions associated with circadian disruption. Overall, the characterization and application of CSNK1D recombinant proteins are crucial for advancing our understanding of its biological functions and therapeutic potential.
