Analytical Data
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基因名
CSNK1D
- Application
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别名
CSNK1D；HCKID;Casein kinase I isoform delta
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P48730
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表达区间
1-415aa
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氨基酸序列
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNISSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
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分子量
54.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSNK1D (casein kinase 1 delta) is a serine/threonine protein kinase that plays a pivotal role in various cellular processes, including circadian rhythm regulation, cell signaling, and protein phosphorylation. Its involvement in the circadian clock highlights its significance in maintaining physiological homeostasis and cellular functions aligned with day-night cycles. Dysregulation of CSNK1D has been linked to various disorders, including sleep disorders, cancer, and metabolic syndromes, prompting significant interest in understanding its mechanisms and potential as a therapeutic target. Research on CSNK1D recombinant proteins has gained traction as these proteins facilitate the elucidation of CSNK1D’s biological roles and interactions at a molecular level. Studies utilizing these recombinant proteins allow for detailed investigations of their enzymatic activity, substrate specificity, and structural dynamics, providing insights into how mutations or aberrant expression of CSNK1D might contribute to disease pathology. Moreover, the development of CSNK1D inhibitors and modulators represents a promising avenue for drug development, particularly in conditions associated with circadian disruption. Overall, the characterization and application of CSNK1D recombinant proteins are crucial for advancing our understanding of its biological functions and therapeutic potential.
