Analytical Data
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Gene name
WDR45
- Application
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Alternative Names
WD repeat-containing protein 45
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y484
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Expression Region
1-360aa
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Molecular Weight
66.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
WDR45 (WD repeat domain 45) is a gene located on the X chromosome, and it is known for its critical role in various cellular processes, including autophagy, neurodevelopment, and cellular stress response. Mutations in the WDR45 gene have been implicated in a range of neurodevelopmental disorders, particularly those characterized by neurodegeneration and cognitive impairment, such as beta-propeller protein-associated neurodegeneration (BPAN). Research into WDR45 recombinantly expressed protein has gained significant attention due to its potential as a biomarker for these disorders and its involvement in cellular mechanisms that maintain neuronal health. Understanding the function of WDR45, notably its interactions with other cellular proteins and its role in autophagy pathways, is crucial for elucidating the molecular basis of associated neurological conditions. Furthermore, recombinant WDR45 protein studies can provide insights into the effects of specific mutations, thereby contributing to the development of targeted therapeutic strategies. As such, ongoing research aims to clarify the biological functions of WDR45 and its relevance to neurodevelopmental disorders, highlighting its role in cell homeostasis and the pathophysiological mechanisms underlying neuronal degeneration. This research landscape underscores the importance of WDR45 in both basic neuroscience and clinical contexts, prompting further exploration into how modulating its function might pave the way for innovative treatments for affected individuals.
