Analytical Data
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Gene name
CNN1
- Application
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Alternative Names
CNN1;Calponin-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51911
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Expression Region
1-297aa
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AA Sequence
MSSAHFNRGP AYGLSAEVKN KLAQKYDHQR EQELREWIEG VTGRRIGNNF MDGLKDGIIL CEFINKLQPG SVKKINESTQ NWHQLENIGN FIKAITKYGV KPHDIFEAND LFENTNHTQV QSTLLALASM AKTKGNKVNV GVKYAEKQER KFEPGKLREG RNIIGLQMGT NKFASQQGMT AYGTRRHLYD PKLGTDQPLD QATISLQMGT NKGASQAGMT APGTKRQIFE PGLGMEHCDT LNVSLQMGSN KGASQRGMTV YGLPRQVYDP KYCLTPEYPE LGEPAHNHHA HNYYNSALEH HHHHH
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Molecular Weight
34 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of the recombinant protein CNN1 (Calponin homology domain-containing protein 1) has garnered attention in the fields of molecular biology and biomedicine due to its potential roles in muscle contraction, cell differentiation, and cytoskeletal dynamics. CNN1 is known for its involvement in regulating actin filament organization and interaction with other proteins, which is critical in maintaining cellular integrity and function. Research has shown that altered expression or dysfunction of CNN1 is associated with various diseases, including cancer and cardiovascular disorders. The recombinant production of CNN1 offers a valuable tool for investigating its structural and functional properties, enabling detailed studies on its role in cellular processes and its potential as a therapeutic target. By expressing CNN1 in heterologous systems, researchers can produce large quantities of the protein, facilitating characterization through techniques such as X-ray crystallography and NMR spectroscopy. Furthermore, understanding the functional mechanisms of CNN1 could pave the way for the development of novel therapeutic strategies for conditions linked to cytoskeletal abnormalities. As such, the investigation of CNN1 recombinant protein represents a promising avenue for both fundamental research and clinical applications, addressing significant gaps in our knowledge regarding cytoskeletal proteins and their contributions to health and disease.
