Analytical Data
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Gene name
S1PR3
- Application
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Alternative Names
S1PR3；C9orf108；C9orf47；EDG3；Sphingosine 1-phosphate receptor 3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99500
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Expression Region
1-378aa
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AA Sequence
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
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Molecular Weight
42.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Sphingosine-1-phosphate receptor 3 (S1PR3) is a G protein-coupled receptor (GPCR) that plays a crucial role in various physiological processes, including immune response, inflammation, and vascular permeability. Research into S1PR3 has gained traction due to its involvement in numerous pathophysiological conditions, such as cardiovascular diseases, cancer, and autoimmune disorders. The receptor has been identified as a potential therapeutic target, prompting efforts to develop S1PR3-specific ligands and modulators. However, the lack of readily available high-quality recombinant S1PR3 protein has hampered detailed studies on its structure, function, and interaction with compounds. To address this gap, researchers have focused on creating recombinant S1PR3 proteins through various expression systems, such as mammalian cells and yeast. These recombinant proteins are essential for elucidating the receptor's signaling mechanisms, identifying potential drug candidates, and advancing the understanding of S1PR3-related diseases. Overall, the study of S1PR3 recombinant proteins represents a significant step towards unlocking the therapeutic potential of this receptor and exploring its role in health and disease.
