Analytical Data
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Gene name
AQP3
- Application
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Alternative Names
AQP3；Aquaporin-3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q92482
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Expression Region
1-292aa
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AA Sequence
MGRQKELVSRCGEMLHIRYRLLRQALAECLGTLILVMFGCGSVAQVVLSRGTHGGFLTINLAFGFAVTLGILIAGQVSGAHLNPAVTFAMCFLAREPWIKLPIYTLAQTLGAFLGAGIVFGLYYDAIWHFADNQLFVSGPNGTAGIFATYPSGHLDMINGFFDQFIGTASLIVCVLAIVDPYNNPVPRGLEAFTVGLVVLVIGTSMGFNSGYAVNPARDFGPRLFTALAGWGSAVFTTGQHWWWVPIVSPLLGSIAGVFVYQLMIGCHLEQPPPSNEEENVKLAHVKHKEQI
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Molecular Weight
31.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Aquaporin-3 (AQP3) is a member of the aquaporin family, which consists of water and solute channels that facilitate the transport of water, glycerol, and other small molecules across the cell membrane. AQP3 is particularly abundant in kidney, skin, and various epithelial tissues, playing a pivotal role in maintaining water homeostasis and regulating osmotic balance. Understanding the structure and function of AQP3 has profound implications for diverse physiological processes, including renal concentration, skin hydration, and cellular metabolism. Research has shown that AQP3 is involved in various pathophysiological conditions, such as dehydration, edema, and even certain cancers, making it a target for therapeutic interventions. The recombinant protein expression of AQP3 allows for detailed biophysical studies and elucidates its functional mechanisms. Purified AQP3 can be studied using techniques such as crystallography and electrophysiology, providing insights into its channel properties and regulatory mechanisms. The ability to produce AQP3 in a laboratory setting also supports drug screening initiatives designed to modulate its activity. Overall, the study of recombinant AQP3 not only enhances our understanding of its biological significance but also opens avenues for innovative treatments related to fluid balance disorders and other AQP3-mediated diseases.
