Analytical Data
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Gene name
CCL2
- Application
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Alternative Names
CCL2；MCP1；SCYA2；C-C motif chemokine 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P13500
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Expression Region
24-99aa
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AA Sequence
QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT
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Molecular Weight
13.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCL2, also known as monocyte chemoattractant protein-1 (MCP-1), is a crucial chemokine involved in the recruitment of monocytes and other immune cells to sites of inflammation and injury. Its role in various physiological and pathological processes, such as immune response, tissue remodeling, and disease progression, has made it a significant target for research. Overexpression of CCL2 has been implicated in several conditions, including autoimmune diseases, cancer, and cardiovascular diseases, highlighting its importance in disease mechanisms. The production of recombinant CCL2 protein allows for detailed studies into its biological functions, interactions with receptors, and potential therapeutic applications. Researchers utilize recombinant techniques to generate CCL2 in sufficient quantities for in vitro and in vivo experiments, facilitating investigations into its signaling pathways and effects on immune cell behavior. Furthermore, understanding the structure-function relationship of CCL2 through recombinant protein studies can lead to the development of novel strategies for managing diseases linked to dysregulated inflammation. Thus, the research into CCL2 recombinant protein not only enhances our comprehension of its fundamental biology but also opens avenues for innovative therapeutic interventions targeting inflammatory and immune-related disorders.
