Analytical Data
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基因名
CCL13
- Application
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别名
CCL13；MCP4；NCC1；SCYA13；C-C motif chemokine 13
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99616
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表达区间
24-98aa
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氨基酸序列
QPDALNVPST CCFTFSSKKI SLQRLKSYVI TTSRCPQKAV IFRTKLGKEI CADPKEKWVQ NYMKHLGRKA HTLKT
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分子量
9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCL13, also known as C-C motif chemokine 13 or monocyte-derived inflammatory protein 1 alpha (MIP-1α), is a member of the chemokine family that plays a crucial role in the immune response by recruiting immune cells to sites of inflammation. Its significance is underscored by its involvement in various pathological conditions, including asthma, atherosclerosis, and other autoimmune diseases. The expression of CCL13 is primarily regulated in response to pro-inflammatory stimuli, and its elevation is often correlated with disease severity. The study of recombinant CCL13 proteins allows researchers to investigate its biological functions, signaling pathways, and interactions with receptors, such as CCR2 and CCR5. Furthermore, these studies are essential for developing therapeutic strategies targeting CCL13 in inflammatory diseases, providing insights into potential interventions that could alleviate chronic inflammation. Recombinant CCL13 can be used in various assays to elucidate its role in cell migration, activation, and the modulation of immune responses. Overall, understanding CCL13 and its mechanisms could lead to novel approaches in treating conditions characterized by aberrant immune activity.
