Analytical Data
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基因名
CPO
- Application
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别名
CPO；Carboxypeptidase O
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P36551
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表达区间
111-454aa
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氨基酸序列
TSLGRPEEEE DELAHRCSSF MAPPVTDLGE LRRRPGDMKT KMELLILETQ AQVCQALAQV DGGANFSVDR WERKEGGGGI SCVLQDGCVF EKAGVSISVV HGNLSEEAAK QMRSRGKVLK TKDGKLPFCA MGVSSVIHPK NPHAPTIHFN YRYFEVEEAD GNKQWWFGGG CDLTPTYLNQ EDAVHFHRTL KEACDQHGPD LYPKFKKWCD DYFFIAHRGE RRGIGGIFFD DLDSPSKEEV FRFVQSCARA VVPSYIPLVK KHCDDSFTPQ EKLWQQLRRG RYVEFNLLYD RGTKFGLFTP GSRIESILMS LPLTARWEYM HSPSENSKEA EILEVLRHPR DWVR
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The study of CPO (cytochrome P450 oxidoreductase) recombinant proteins has garnered significant attention due to their indispensable role in various biological processes, particularly in drug metabolism and the biosynthesis of steroids and other biochemical molecules. CPO is a flavoprotein that serves as a crucial electron donor, facilitating the activity of cytochrome P450 enzymes, which are essential for the oxidative metabolism of a broad range of substrates, including pharmaceuticals, toxins, and endogenous compounds. Variations in CPO activity can lead to altered drug responses and toxicity, making it critical to understand its functionality. Advances in recombinant DNA technology have enabled the production of CPO proteins in heterologous systems, allowing for detailed studies on their biochemical properties, stability, and interactions with other metabolic enzymes. Investigating the structure-function relationship of CPO can provide insights into its mechanisms of action and potential applications in pharmacogenomics, toxicology, and biotechnology. With the increasing complexity of drug development and personalized medicine, understanding CPO's role opens avenues for the optimization of therapeutic regimens and the mitigation of adverse drug reactions, thus highlighting the significance of ongoing research in this domain.
