Analytical Data
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Gene name
CES5A
- Application
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Alternative Names
CES5A；CES7；Carboxylesterase 5A
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q6NT32
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Expression Region
21-575aa
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AA Sequence
APTKGPSAEG PQRNTRLGWI QGKQVTVLGS PVPVNVFLGV PFAAPPLGSL RFTNPQPASP WDNLREATSY PNLCLQNSEW LLLDQHMLKV HYPKFGVSED CLYLNIYAPA HADTGSKLPV LVWFPGGAFK TGSASIFDGS ALAAYEDVLV VVVQYRLGIF GFFTTWDQHA PGNWAFKDQV AALSWVQKNI EFFGGDPSSV TIFGESAGAI SVSSLILSPM AKGLFHKAIM ESGVAIIPYL EAHDYEKSED LQVVAHFCGN NASDSEALLR CLRTKPSKEL LTLSQKTKSF TRVVDGAFFP NEPLDLLSQK AFKAIPSIIG VNNHECGFLL PMKEAPEILS GSNKSLALHL IQNILHIPPQ YLHLVANEYF HDKHSLTEIR DSLLDLLGDV FFVVPALITA RYHRDAGAPV YFYEFRHRPQ CFEDTKPAFV KADHADEVRF VFGGAFLKGD IVMFEGATEE EKLLSRKMMK YWATFARTGN PNGNDLSLWP AYNLTEQYLQ LDLNMSLGQR LKEPRVDFWT STIPLILSAS DMLHSPLSSL TFLSLLQPFF FFCAP
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CES5A (Carboxylesterase 5A) is a member of the carboxylesterase enzyme family, known for its role in hydrolyzing ester and amide bonds in various substrates, including drugs, pesticides, and endogenous compounds. This enzyme is particularly significant due to its involvement in drug metabolism and detoxification processes, which influence the pharmacokinetics and efficacy of therapeutics. Recent studies have highlighted CES5A's potential role in influencing the metabolism of certain biologically active compounds, affecting their bioavailability and therapeutic outcomes. With the increasing complexity of drug interactions and metabolic pathways, understanding CES5A's structure, function, and regulation becomes crucial for optimizing drug design and minimizing adverse effects. Additionally, CES5A's differential expression in various tissues and its association with certain diseases make it a promising target for further research. Investigating the recombinant expression of CES5A can provide insights into its biochemical properties and facilitate the development of inhibitors or activators that could enhance therapeutic strategies or mitigate side effects in clinical settings. Overall, the study of CES5A holds significant promise for advancing our understanding of metabolic processes and improving the safety and efficacy of pharmacological agents.
