Analytical Data
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基因名
CBX3
- Application
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别名
CBX3;Chromobox Protein homolog 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13185
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表达区间
1-183aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSHMASNKT TLQKMGKKQN GKSKKVEEAE PEEFVVEKVL DRRVVNGKVE YFLKWKGFTD ADNTWEPEEN LDCPELIEAF LNSQKAGKEK DGTKRKSLSD SESDDSKSKK KRDAADKPRG FARGLDPERI IGATDSSGEL MFLMKWKDSD EADLVLAKEA NMKCPQIVIA FYEERLTWHS CPEDEAQ
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分子量
23 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CBX3, also known as Chromobox 3 or HP1γ, is a member of the heterochromatin protein 1 (HP1) family, which plays a crucial role in the regulation of gene expression, chromosome structure, and epigenetic inheritance. Its involvement in heterochromatin formation and maintenance highlights its importance in gene silencing and genome stability. Recent studies have revealed that CBX3 is not only essential for normal cellular function but also implicated in various diseases, including cancer, where its dysregulation can lead to altered gene expression patterns that promote tumorigenesis. Additionally, CBX3 has been observed to participate in critical cellular processes such as DNA repair, cell cycle regulation, and stem cell differentiation. The ability to produce recombinant CBX3 protein is vital for advancing our understanding of its structure-function relationships and its mechanisms of action in cellular contexts. Research utilizing CBX3 recombinant protein opens avenues for investigating its role in chromatin dynamics, protein-protein interactions, and its potential as a therapeutic target. Characterizing the biochemical properties of CBX3, including its binding affinities and interaction partners, could provide insights into the molecular pathways it governs. As studies continue to uncover the multifaceted roles of CBX3, the generation and utilization of its recombinant form promise to enhance our comprehension of its contributions to cellular homeostasis and its implications in human health and disease.












