Analytical Data
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基因名
MTTP
- Application
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别名
MTTP；MTP；Microsomal triglyceride transfer Protein large subunit
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P55157
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表达区间
1-894aa
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氨基酸序列
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
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分子量
99.3 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MTTP (Microsomal Triglyceride Transfer Protein) is a key player in lipid metabolism, particularly in the transport and assembly of lipoproteins in the liver and intestine. This protein facilitates the transfer of triglycerides and other lipids to nascent lipoprotein particles, which is crucial for the formation of very-low-density lipoproteins (VLDL) and chylomicrons. Dysregulation of MTTP function can lead to various metabolic disorders, including dyslipidemia and non-alcoholic fatty liver disease (NAFLD). Consequently, MTTP has garnered significant interest in biomedical research as a potential therapeutic target for these conditions. Studies have demonstrated that mutations in the MTTP gene can result in severe lipid absorption disorders, underscoring the protein's importance in maintaining lipid homeostasis. Furthermore, the exploration of MTTP's role in various metabolic pathways has implications for understanding cardiovascular diseases, diabetes, and obesity. Researchers are focusing on the development of recombinant MTTP proteins to study its structure-function relationships, enzyme kinetics, and interactions with other lipid-related proteins. These recombinant proteins are invaluable for investigating the mechanisms underlying MTTP's role in lipoprotein metabolism, potentially leading to novel therapeutic strategies aimed at improving lipid profiles and reducing the risk of associated diseases. The ongoing research into MTTP highlights its central role in metabolic health and disease, making it a promising target for future clinical interventions.
