Analytical Data
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Gene name
MTTP
- Application
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Alternative Names
MTTP；MTP；Microsomal triglyceride transfer Protein large subunit
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P55157
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Expression Region
1-894aa
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AA Sequence
MILLAVLFLCFISSYSASVKGHTTGLSLNNDRLYKLTYSTEVLLDRGKGKLQDSVGYRISSNVDVALLWRNPDGDDDQLIQITMKDVNVENVNQQRGEKSIFKGKSPSKIMGKENLEALQRPTLLHLIHGKVKEFYSYQNEAVAIENIKRGLASLFQTQLSSGTTNEVDISGNCKVTYQAHQDKVIKIKALDSCKIARSGFTTPNQVLGVSSKATSVTTYKIEDSFVIAVLAEETHNFGLNFLQTIKGKIVSKQKLELKTTEAGPRLMSGKQAAAIIKAVDSKYTAIPIVGQVFQSHCKGCPSLSELWRSTRKYLQPDNLSKAEAVRNFLAFIQHLRTAKKEEILQILKMENKEVLPQLVDAVTSAQTSDSLEAILDFLDFKSDSSIILQERFLYACGFASHPNEELLRALISKFKGSIGSSDIRETVMIITGTLVRKLCQNEGCKLKAVVEAKKLILGGLEKAEKKEDTRMYLLALKNALLPEGIPSLLKYAEAGEGPISHLATTALQRYDLPFITDEVKKTLNRIYHQNRKVHEKTVRTAAAAIILNNNPSYMDVKNILLSIGELPQEMNKYMLAIVQDILRFEMPASKIVRRVLKEMVAHNYDRFSRSGSSSAYTGYIERSPRSASTYSLDILYSGSGILRRSNLNIFQYIGKAGLHGSQVVIEAQGLEALIAATPDEGEENLDSYAGMSAILFDVQLRPVTFFNGYSDLMSKMLSASGDPISVVKGLILLIDHSQELQLQSGLKANIEVQGGLAIDISGAMEFSLWYRESKTRVKNRVTVVITTDITVDSSFVKAGLETSTETEAGLEFISTVQFSQYPFLVCMQMDKDEAPFRQFEKKYERLSTGRGYVSQKRKESVLAGCEFPLHQENSEMCKVVFAPQPDSTSSGWF
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Molecular Weight
99.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MTTP (Microsomal Triglyceride Transfer Protein) is a key player in lipid metabolism, particularly in the transport and assembly of lipoproteins in the liver and intestine. This protein facilitates the transfer of triglycerides and other lipids to nascent lipoprotein particles, which is crucial for the formation of very-low-density lipoproteins (VLDL) and chylomicrons. Dysregulation of MTTP function can lead to various metabolic disorders, including dyslipidemia and non-alcoholic fatty liver disease (NAFLD). Consequently, MTTP has garnered significant interest in biomedical research as a potential therapeutic target for these conditions. Studies have demonstrated that mutations in the MTTP gene can result in severe lipid absorption disorders, underscoring the protein's importance in maintaining lipid homeostasis. Furthermore, the exploration of MTTP's role in various metabolic pathways has implications for understanding cardiovascular diseases, diabetes, and obesity. Researchers are focusing on the development of recombinant MTTP proteins to study its structure-function relationships, enzyme kinetics, and interactions with other lipid-related proteins. These recombinant proteins are invaluable for investigating the mechanisms underlying MTTP's role in lipoprotein metabolism, potentially leading to novel therapeutic strategies aimed at improving lipid profiles and reducing the risk of associated diseases. The ongoing research into MTTP highlights its central role in metabolic health and disease, making it a promising target for future clinical interventions.
