Analytical Data
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Gene name
CALR3
- Application
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Alternative Names
CALR3；CRT2；Calreticulin-3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96L12
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Expression Region
20-384aa
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AA Sequence
MTVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHKEKDKGLQT TQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADID QKNLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGF THLYTLILRPDLSYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWE QTKDNKAQDWEKHFLDASTSKQSDWNGDLDGDWPAPMLQKPPYQDGLKPE GIHKDVWLHRKMKNTDYLTQYDLSEFENIGAIGLELWQVRSGTIFDNFLI TDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEEEELLSGKI NRHEHYFNQFHRRNEL
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Molecular Weight
43 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The study of CALR3 (calreticulin 3), an endoplasmic reticulum chaperone protein, has gained significant attention due to its crucial roles in cellular functions, including calcium homeostasis, protein folding, and immune response regulation. CALR3 is predominantly expressed in various tissues, particularly in the brain and heart, suggesting its involvement in essential physiological processes. Recent research indicates that CALR3 may also play a role in cancer biology and developmental disorders, raising questions about its potential implications in these diseases. The recombinant production of CALR3 proteins facilitates in-depth structural and functional studies, enabling researchers to investigate the molecular mechanisms underlying its interactions and activities. By utilizing advanced techniques in molecular biology and protein engineering, the expression and purification of CALR3 can be optimized, thus allowing for the exploration of its biochemical properties and potential therapeutic applications. Understanding CALR3's function and regulatory pathways could provide valuable insights into its role in health and disease, paving the way for novel strategies in treating conditions linked to its dysfunction. As a result, the recombinant CALR3 protein serves as a pivotal tool in unraveling the complexities of cellular homeostasis and its contributions to various biological processes.
