Analytical Data
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Gene name
CALN1
- Application
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Alternative Names
CALN1；CABP8；Calcium-binding Protein 8
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BXU9
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Expression Region
1-192aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MPFHHVTAGL LYKGNYLNRS LSAGSDSEQL ANISVEELDE IREAFRVLDR DGNGFISKQE LGMAMRSLGY MPSEVELAII MQRLDMDGDG QVDFDEFMTI LGPKLVSSEG RDGFLGNTID SIFWQFDMQR ITLEELKHIL YHAFRDHLTM KDIENIIINE EESLNETSGN CQTEFEGVHS QKQNRQTCVR KS
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Molecular Weight
24 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CALN1, or Calcium-binding protein 1, is a member of the calmodulin superfamily of proteins and plays a crucial role in calcium signaling within neurons. Its involvement in various physiological processes, including synaptic transmission and neuronal plasticity, has drawn significant interest in both basic and clinical research. Mutations and dysregulation of CALN1 have been implicated in several neurodevelopmental disorders and neurological diseases, suggesting its vital role in maintaining neuronal health and function. Recent studies have focused on the production and characterization of recombinant CALN1 protein to elucidate its structure-function relationship, particularly its calcium-binding properties and interaction with other proteins. By employing techniques such as molecular cloning, expression in host systems, and biochemical assays, researchers aim to dissect the functional mechanisms of CALN1 in neuronal contexts. Moreover, understanding CALN1's role could lead to potential therapeutic targets for diseases associated with calcium dysregulation. Overall, the exploration of CALN1 recombinant protein offers promising insights into neuronal signaling pathways and their implications in health and disease.
