Analytical Data
-
Gene name
CALB2
- Application
-
Alternative Names
CALB2；CAB29；Calretinin
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P22676
-
Expression Region
1-271aa
-
AA Sequence
MGSSHHHHHH SSGLVPRGSH MAGPQQQPPY LHLAELTASQ FLEIWKHFDA DGNGYIEGKE LENFFQELEK ARKGSGMMSK SDNFGEKMKE FMQKYDKNSD GKIEMAELAQ ILPTEENFLL CFRQHVGSST EFMEAWRKYD TDRSGYIEAN ELKGFLSDLL KKANRPYDEP KLQEYTQTIL RMFDLNGDGK LGLSEMSRLL PVQENFLLKF QGMKLTSEEF NAIFTFYDKD RSGYIDEHEL DALLKDLYEK NKKEMNIQQL TNYRKSVMSL AEAGKLYRKD LEIVLCSEPP M
-
Molecular Weight
34 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CALB2, or Calbindin-2, is a calcium-binding protein that plays a crucial role in calcium homeostasis and signaling in various cell types, particularly in neurons and muscle tissues. It is part of the EF-hand protein family, which is characterized by a helix-loop-helix structural motif that facilitates calcium ion binding. Research into CALB2 has gained attention due to its involvement in key physiological processes, such as synaptic transmission, neuronal plasticity, and muscle contraction. Abnormal CALB2 expression has been implicated in various neurological disorders, cardiovascular diseases, and muscle pathologies. Scientists have conducted extensive studies to understand its molecular mechanisms, including the effects of CALB2 on intracellular calcium levels and its interactions with other proteins. Recombinant CALB2 proteins have been produced to facilitate these studies and to explore potential therapeutic applications. By utilizing techniques such as site-directed mutagenesis and expression in heterologous systems, researchers aim to dissect the functional roles of CALB2 in health and disease. Understanding CALB2’s interactions and regulatory roles could pave the way for novel diagnostic and therapeutic strategies, particularly in the context of calcium-related diseases. The continued investigation into CALB2 recombinants will enhance our understanding of calcium dynamics in cellular processes, contributing to the broader field of cell signaling and neurobiology.
