Analytical Data
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基因名
MAP2
- Application
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别名
MAP2；Microtubule-associated Protein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11137-2
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表达区间
1-471aa
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氨基酸序列
MADERKDEAKAPHWTSAPLTEASAHSHPPEIKDQGGAGEGLVRSANGFPY REDEEGAFGEHGSQGTYSNTKENGINGELTSADRETAEEVSARIVQVVTA EAVAVLKGEQEKEAQHKDQTAALPLAAEETANLPPSPPPSPASEQTVTVE EAAGGESALAPSVFKQAKDKVSDGVTKSPEKRSSLPRPSSILPPRRGVSG DRDENSFSLNSSISSSARRTTRSEPIRRAGKSGTSTPTTPGSTAITPGTP PSYSSRTPGTPGTPSYPRTPHTPGTPKSAILVPSEKKVAIIRTPPKSPAT PKQLRLINQPLPDLKNVKSKIGSTDNIKYQPKGGQVQIVTKKIDLSHVTS KCGSLKNIRHRPGGGRVKIESVKLDFKEKAQAKVGSLDNAHHVPGGGNVK IDSQKLNFREHAKARVDHGAEIITQSPGRSSVASPRRLSNVSSSGSINLL ESPQLATLAEDVTAALAKQGL
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分子量
78 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
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Protein Description
MAP2 (Microtubule-Associated Protein 2) is a prominent member of the MAP family, primarily expressed in neurons, where it plays a critical role in stabilizing microtubules and maintaining the structural integrity of dendrites. Research on MAP2 has gained significant attention due to its involvement in neurodevelopment, synaptic plasticity, and neurodegenerative diseases. Abnormalities in MAP2 expression or function have been associated with conditions such as Alzheimer's disease, where hyperphosphorylation of MAP2 can lead to disrupted microtubule dynamics and neuronal degeneration. The study of recombinant MAP2 proteins allows researchers to investigate the protein's biochemical properties, interactions with microtubules, and the effects of post-translational modifications. By expressing MAP2 in a recombinant system, scientists can produce sufficient quantities of the protein for structural and functional analyses, paving the way for potential therapeutic strategies targeting dysregulated MAP2 pathways in neurodegenerative disorders. Understanding the molecular mechanisms underlying MAP2's role in cellular processes may provide insights into neuronal resilience and the development of treatments for various neurological conditions.
