Analytical Data
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Gene name
PLEC
- Application
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Alternative Names
PLEC；PLEC1；Plectin
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q15149
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Expression Region
全长
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AA Sequence
full
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PLEC (plectin) is a versatile cytoskeletal protein that plays crucial roles in cellular integrity, signaling, and mechanotransduction. It acts as a crosslinker between intermediate filaments and other cellular structures, contributing to the maintenance of cell shape, providing mechanical strength, and facilitating cellular responses to environmental stresses. Research into PLEC has gained momentum due to its association with various diseases, including cancer, skin disorders, and muscular dystrophies. Mutations in the PLEC gene can lead to a loss of function, severely affecting cellular architecture and contributing to disease pathology. Understanding the structure and function of PLEC, as well as the mechanisms by which it interacts with other proteins and the cytoskeleton, is vital for elucidating its role in health and disease. This has prompted the development of recombinant PLEC proteins for detailed studies on protein-protein interactions, mechanistic pathways, and potential therapeutic interventions. By producing these recombinant proteins, researchers can explore the functional domains of PLEC, characterize its binding partners, and investigate its involvement in various cellular processes. This research not only aids in deciphering the fundamental biology of PLEC but also opens avenues for targeted therapies aimed at diseases linked to its dysfunction, highlighting the importance of PLEC in both basic and applied biomedical research.
