Analytical Data
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基因名
PMP22
- Application
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别名
PMP22；GAS3；Peripheral myelin Protein 22
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q01453
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表达区间
1-160aa
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氨基酸序列
MLLLLLSIIVLHVAVLVLLFVSTIVSQWIVGNGHATDLWQNCSTSSSGNV HHCFSSSPNEWLQSVQATMILSIIFSILSLFLFFCQLFTLTKGGRFYITG IFQILAGLCVMSAAAIYTVRHPEWHLNSDYSYGFAYILAWVAFPLALLSG VIYVILRKRE
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分子量
45 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PMP22 (Peripheral Myelin Protein 22) is a key player in the formation and maintenance of myelin, the protective sheath surrounding nerve fibers in the peripheral nervous system. Mutations and dysregulation of the PMP22 gene are associated with several hereditary neuropathies, including Charcot-Marie-Tooth disease type 1A (CMT1A), which leads to progressive muscle weakness and sensory loss. Understanding the structural and functional properties of PMP22 is crucial for elucidating the mechanisms underlying these neuropathies. Recombinant PMP22 proteins are used in various research applications to study its role in myelin formation, cellular signaling, and interactions with other myelin-related proteins. Furthermore, the study of PMP22 may pave the way for the development of targeted therapies aimed at ameliorating the symptoms of hereditary neuropathies. Research utilizing recombinant PMP22 proteins helps clarify how variations in this protein affect nerve function and contribute to disease pathology, ultimately guiding diagnostic and therapeutic strategies for affected individuals.
