Analytical Data
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基因名
MTNR1A
- Application
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别名
MTNR1A;Melatonin receptor type 1A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P48039
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表达区间
296-350aa
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氨基酸序列
GLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVV KVDSV
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分子量
32 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MTNR1A, the melatonin receptor type 1A, plays a critical role in regulating various physiological processes through its interaction with melatonin, a hormone primarily involved in the regulation of circadian rhythms and sleep-wake cycles. Research on MTNR1A has gained momentum due to its implications in sleep disorders, mood regulation, and reproductive functions. As a G protein-coupled receptor (GPCR), MTNR1A activates intracellular signaling pathways when bound by melatonin, influencing neuronal activity and various metabolic processes. The exploration of MTNR1A and its recombinant protein has become increasingly important in pharmacology and therapeutic applications, particularly in the context of developing new treatments for insomnia, depression, and anxiety disorders. Additionally, the understanding of MTNR1A's structure and function can facilitate the design of selective ligands that may enhance or inhibit its activity, offering potential advances in personalized medicine. The production of recombinant MTNR1A protein allows for detailed biochemical studies, contributing to our understanding of receptor dynamics, ligand binding, and signaling mechanisms. Overall, the research on MTNR1A recombinant proteins holds promise not only for elucidating the complex biology of melatonin signaling but also for the development of innovative therapeutic strategies targeting related health issues.












