Analytical Data
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基因名
BSND
- Application
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别名
BSND；BART；Barttin
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8WZ55
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表达区间
54-320aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSCQCYPKITFVPADSDFQGILSPKAMGL LENGLAAEMKSPSPQPPYVRLWEEAAYDQSLPDFSHIQMKVMSYSEDHRS LLAPEMGQPKLGTSDGGEGGPGDVQAWMEAAVVIHKGSDESEGERRLTQS WPGPLACPQGPAPLASFQDDLDMDSSEGSSPNASPHDREEACSPQQEPQG CRCPLDRFQDFALIDAPTLEDEPQEGQQWEIALPNNWQRYPRTKVEEKEA SDTGGEEPEKEEEDLYYGLPDGAGDLLPDKELGFEPDTQG
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分子量
32 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The research on BSND (Bartter syndrome, neonatal type) recombinant protein stems from its crucial role in renal function and electrolyte homeostasis. BSND is a protein associated with Bartter syndrome, a genetic disorder characterized by renal salt wasting, hypokalemic metabolic alkalosis, and growth impairment in infants and children. The gene encoding BSND is vital for the proper functioning of the Na+-K+-2Cl- co-transporter in the thick ascending limb of the loop of Henle, which is essential for potassium and sodium reabsorption. Mutations in the BSND gene lead to dysfunctional renal tubular transport, resulting in the clinical manifestations of Bartter syndrome. Consequently, the study of BSND recombinant protein allows researchers to explore its structure, function, and interaction with other renal proteins, which can shed light on the pathophysiology of the disorder. Furthermore, understanding the mechanisms underlying BSND-related renal transport could pave the way for potential therapeutic strategies for managing Bartter syndrome and related electrolyte disorders, ultimately improving patient outcomes. This research also contributes to the broader field of renal physiology and may provide insights into other diseases pertaining to electrolyte imbalance, making BSND an important target for ongoing investigations.
