Analytical Data
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Gene name
BRICK1
- Application
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Alternative Names
BRICK1；C3orf10；Protein BRICK1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WUW1
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Expression Region
2-75aa
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AA Sequence
AGQEDPVQR EIHQDWANRE YIEIITSSIK KIADFLNSFD MSCRSRLATL NEKLTALERR IEYIEARVTK GETLT
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
BRICK1, a crucial protein involved in the regulation of autophagy and endocytosis, has garnered significant attention in recent years due to its implications in cellular homeostasis and disease pathology. Initially identified as a component of the BRCA1-A complex, BRICK1 plays a vital role in the cellular response to stressors and nutrient availability by mediating vesicle trafficking and promoting the degradation of misfolded proteins. Its dysfunction has been linked to various cancers and neurodegenerative diseases, underscoring the need for a deeper understanding of its mechanistic functions. Recent research has focused on the structural characterization and functional analyses of BRICK1, utilizing recombinant techniques to produce purified protein for biochemical studies. By elucidating the molecular pathways that BRICK1 influences, researchers aim to uncover potential therapeutic targets for diseases characterized by impaired autophagy and endosomal trafficking. Furthermore, the development of BRICK1 transgenic models is providing valuable insights into its role in vivo, enhancing our understanding of its physiological relevance. Overall, the study of BRICK1 not only contributes to the fundamental knowledge of cellular processes but also paves the way for innovative approaches in disease treatment and prevention.
