Analytical Data
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Gene name
BRMS1
- Application
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Alternative Names
BRMS1；Breast cancer metastasis-suppressor 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HCU9
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Expression Region
1-246aa
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AA Sequence
MASMTGGQQM GRGSHMPVQP PSKDTEEMEA EGDSAAEMNG EEEESEEERS GSQTESEEES SEMDDEDYER RRSECVSEML DLEKQFSELK EKLFRERLSQ LRLRLEEVGA ERAPEYTEPL GGLQRSLKIR IQVAGIYKGF CLDVIRNKYE CELQGAKQHL ESEKLLLYDT LQGELQERIQ RLEEDRQSLD LSSEWWDDKL HARGSSRSWD SLPPSKRKKA PLVSGPYIVY MLQEIDILED WTAIKKARAA VSPQKRKSDG P
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Molecular Weight
30 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BRMS1 (Breast Cancer Metastasis Suppressor 1) is a protein that plays a critical role in tumor biology, particularly in breast cancer metastasis. Its primary function is to inhibit metastasis without affecting primary tumor growth, making it a target of interest in cancer research. The protein is encoded by the BRMS1 gene, and its expression has been associated with improved survival rates in patients with breast cancer. Research has demonstrated that BRMS1 interacts with several signaling pathways and transcription factors involved in cancer progression, suggesting its role as a key modulator in the metastatic cascade. Moreover, the loss of BRMS1 expression has been correlated with increased metastatic potential in various cancer types, indicating its potential as a biomarker for prognosis. Recent studies have focused on understanding the molecular mechanisms underlying BRMS1's function, exploring its interactions at the cellular level, and investigating its potential therapeutic applications. As breast cancer continues to be a significant global health challenge, elucidating the role of BRMS1 could lead to advancements in treatment strategies aimed at preventing metastasis and improving patient outcomes.
