Analytical Data
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Gene name
CBLN1
- Application
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Alternative Names
CBLN1；Cerebellin-1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P23435
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Expression Region
22-193aa
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AA Sequence
QNETEPIVL EGKCLVVCDS NPTSDPTGTA LGISVRSGSA KVAFSAIRST NHEPSEMSNR TMIIYFDQVL VNIGNNFDSE RSTFIAPRKG IYSFNFHVVK VYNRQTIQVS LMLNGWPVIS AFAGDQDVTR EAASNGVLIQ MEKGDRAYLK LERGNLMGGW KYSTFSGFLV FPL
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CBLN1 (Cerebellar-brain protein 1) is a member of the CBLN family of proteins, primarily expressed in the brain, where it plays critical roles in synaptic function and neuronal connectivity. Research into CBLN1 has gained traction due to its potential implications in neurological disorders, particularly those affecting synaptic transmission and plasticity. Its unique structure and expression profile suggest that CBLN1 may contribute to the maintenance of synaptic integrity and the modulation of excitatory and inhibitory neurotransmission. Studies have indicated that CBLN1 is involved in the formation and stabilization of synapses, particularly in the cerebellum, which is essential for motor coordination and cognitive processes. Furthermore, disruptions in CBLN1 signaling have been associated with various neurodevelopmental and psychiatric conditions, prompting investigations into its role as a biomarker and therapeutic target. The exploration of CBLN1 recombinant protein, generated through genetic engineering techniques, allows for detailed biochemical and functional analyses, offering insights into its molecular mechanisms and interactions with other synaptic proteins. This research is crucial for understanding the underlying pathophysiology of synaptic disorders and may pave the way for the development of novel therapeutic strategies aimed at restoring normal synaptic function in affected individuals. Overall, CBLN1 stands at the intersection of neurobiology and clinical research, highlighting its significance in the quest to unravel the complexities of brain function and dysfunction.
