Analytical Data
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Gene name
MTERF
- Application
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Alternative Names
MTERF；MTERF；Transcription termination factor 1. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q49AM1
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Expression Region
36-385aa
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AA Sequence
TTDKQ SSKENTRTVE KLYKCSVDIR KIRRLKGWVL LEDETYVEEI ANILQELGAD ETAVASILER CPEAIVCSPT AVNTQRKLWQ LVCKNEEELI KLIEQFPESF FTIKDQENQK LNVQFFQELG LKNVVISRLL TAAPNVFHNP VEKNKQMVRI LQESYLDVGG SEANMKVWLL KLLSQNPFIL LNSPTAIKET LEFLQEQGFT SFEILQLLSK LKGFLFQLCP RSIQNSISFS KNAFKCTDHD LKQLVLKCPA LLYYSVPVLE ERMQGLLREG ISIAQIRETP MVLELTPQIV QYRIRKLNSS GYRIKDGHLA NLNGSKKEFE ANFGKIQAKK VRPLFNPVAP LNVEE
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MTERF (mitochondrial transcription termination factor) proteins play a crucial role in the regulation of mitochondrial gene expression, which is essential for maintaining mitochondrial function and cellular energy metabolism. These proteins specifically bind to mitochondrial DNA and facilitate the termination of transcription, thereby influencing the levels of various mitochondrial transcripts. Research on MTERF proteins has gained momentum due to their potential implications in various diseases, including neurodegenerative disorders and metabolic syndromes, where mitochondrial dysfunction is often a key factor. Understanding the mechanisms by which MTERF proteins modulate mitochondrial transcription can provide insights into how they contribute to cellular homeostasis and may reveal novel therapeutic targets for treating mitochondrial-related diseases. Recent studies have focused on elucidating the structural characteristics of these proteins and their interaction with other mitochondrial factors, which could lead to the discovery of new regulatory pathways within mitochondria. Additionally, the role of MTERF proteins in the maintenance of mitochondrial dynamics and their involvement in apoptosis and oxidative stress response are areas of active investigation. Overall, the study of MTERF recombinant proteins is not only fundamental for understanding mitochondrial biology but also holds promise for advancing strategies to combat various mitochondrial pathology.
