Analytical Data
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Gene name
C5AR1
- Application
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Alternative Names
C5a anaphylatoxin chemotactic receptor;C5a-R;C5aR;CD88
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Species
Human
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Source
E. coli
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Tag
C- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P21730
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Expression Region
1-350aa
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Molecular Weight
40.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
C5AR1, also known as the complement component 5a receptor 1, is a G protein-coupled receptor that plays a crucial role in the immune response by mediating the effects of the anaphylatoxin C5a, which is generated during the complement activation process. This receptor is involved in various physiological and pathological processes, including inflammation, chemotaxis, and cell activation, making it a significant target for therapeutic intervention in conditions such as sepsis, autoimmune diseases, and cancer. Given the increasing interest in understanding the intricacies of the immune system, research on C5AR1 has expanded considerably. Scientists are focusing on the structural characterization, signaling pathways, and ligand interactions of C5AR1 to develop potential drugs that can selectively modulate its activity, thereby providing better control over inflammatory responses. Additionally, the generation of recombinant C5AR1 protein has facilitated the study of its functional roles and helped elucidate its mechanisms in disease pathology, promoting advancements in pharmacological therapies aimed at mitigating excessive inflammation and improving patient outcomes. Understanding the biology and therapeutic potential of C5AR1 is crucial for the development of novel strategies to combat a wide array of immune-related disorders.
