Analytical Data
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基因名
ZIC2
- Application
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别名
Zinc finger protein of the cerebellum 2
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种属
Human
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表达系统
E. coli
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标签
N- His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95409
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表达区间
100-415aa
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分子量
41.6 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ZIC2 is a member of the Zinc Finger of the Cerebellum (ZIC) family of transcription factors, which play crucial roles in the early development of the central nervous system and limb patterning. Research into ZIC2 has gained significant attention due to its implications in various neurodevelopmental disorders, particularly because mutations or dysregulation of ZIC2 have been linked to holoprosencephaly, a condition characterized by the incomplete separation of the brain hemispheres. Studies have highlighted ZIC2's involvement in the regulation of neural progenitor cell differentiation and the establishment of the midline during embryogenesis. Recent advances in recombinant protein technology have enabled the production and study of ZIC2, allowing scientists to investigate its biochemical properties, interaction with other proteins, and functional pathways in greater detail. Understanding the mechanisms by which ZIC2 influences developmental processes could provide insights into therapeutic strategies for congenital malformations and other neurological conditions. Overall, the study of ZIC2 recombinant protein serves as a pivotal area of research that bridges molecular biology with developmental neuroscience, offering potential avenues for innovative medical interventions.
