Analytical Data
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Gene name
ZIC2
- Application
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Alternative Names
Zinc finger protein of the cerebellum 2
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Species
Human
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Source
E. coli
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Tag
N- His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95409
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Expression Region
100-415aa
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Molecular Weight
41.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
ZIC2 is a member of the Zinc Finger of the Cerebellum (ZIC) family of transcription factors, which play crucial roles in the early development of the central nervous system and limb patterning. Research into ZIC2 has gained significant attention due to its implications in various neurodevelopmental disorders, particularly because mutations or dysregulation of ZIC2 have been linked to holoprosencephaly, a condition characterized by the incomplete separation of the brain hemispheres. Studies have highlighted ZIC2's involvement in the regulation of neural progenitor cell differentiation and the establishment of the midline during embryogenesis. Recent advances in recombinant protein technology have enabled the production and study of ZIC2, allowing scientists to investigate its biochemical properties, interaction with other proteins, and functional pathways in greater detail. Understanding the mechanisms by which ZIC2 influences developmental processes could provide insights into therapeutic strategies for congenital malformations and other neurological conditions. Overall, the study of ZIC2 recombinant protein serves as a pivotal area of research that bridges molecular biology with developmental neuroscience, offering potential avenues for innovative medical interventions.
