Analytical Data
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Gene name
LSM1
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简介
LSM1 protein participates in the degradation of histone mRNAs, unique among eukaryotic mRNAs for lacking polyadenylation.Likely part of an LSm subunit-containing complex involved in general mRNA degradation.It interacts with SLBP, particularly during rapid histone mRNA degradation in the S phase.The LSm subunits collectively form a donut-shaped heteromer.LSM1 Protein, Human (His) is the recombinant human-derived LSM1 protein, expressed by E.coli , with C-6*His labeled tag.
- Application
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Alternative Names
rHuU6 snRNA-associated Sm-like protein LSm1, His; U6 snRNA-Associated Sm-Like Protein LSm1; Cancer-Associated Sm-Like; Small Nuclear Ribonuclear CaSm; LSM1; CASM
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Species
Human
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Source
E. coli
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15116
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Expression Region
M1-Y133
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Protein Length
Full Length
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Molecular Weight
19 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
LSM1 (Like Sm protein 1) is a crucial component of the Lsm (Like Sm) protein family, which plays vital roles in RNA metabolism, including mRNA stability, processing, and decay. The LSM1 protein is particularly significant in the regulation of the cytoplasmic mRNA decay pathway and has been linked to the modulation of gene expression. Research on LSM1 has gained momentum due to its involvement in various cellular processes and its implications in diseases, principally cancer and neurodegenerative disorders. Previous studies have shown that LSM1 interacts with other proteins and RNA substrates, forming essential complexes that facilitate the recruitment of decapping enzymes and exoribonucleases to mRNA. Understanding the structural and functional aspects of LSM1 is critical for uncovering the molecular mechanisms governing RNA metabolism. Additionally, advancements in recombinant protein technology have made it feasible to produce LSM1 in vitro, allowing for detailed biochemical and biophysical analyses. The study of recombinant LSM1 proteins has the potential to reveal insights into their interaction partners, post-translational modifications, and overall role in cellular health and disease. As researchers delve deeper into the characteristics and functions of LSM1, the findings could pave the way for therapeutic strategies aimed at modulating RNA decay and potentially addressing disorders linked to aberrant RNA metabolism. Thus, LSM1 represents a significant focal point in molecular biology, warranting extensive investigation into its role in the broader context of gene regulation and cellular function.
