Analytical Data
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基因名
MT-ND1
- Application
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别名
NADH dehydrogenase subunit 1 MTND1, NADH1, ND1
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种属
Lampetra fluviatilis
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O21069
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表达区间
1-321aa
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分子量
53.8 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MT-ND1, a subunit of mitochondrial complex I, is crucial for cellular respiration and energy production. It plays a vital role in the electron transport chain, contributing to ATP synthesis. Mutations in the MT-ND1 gene are implicated in various mitochondrial disorders, which can lead to neurodegenerative diseases, muscle weakness, and developmental issues. Given these significant associations, understanding the structure and function of MT-ND1 is essential for elucidating the pathophysiology of mitochondrial diseases. Researchers focus on characterizing its protein structure through methods like X-ray crystallography and cryo-electron microscopy, which can reveal insights into its interactions with other complex I subunits. This knowledge may lead to the development of targeted therapies aimed at mitigating the effects of MT-ND1-related mitochondrial dysfunction. The exploration of MT-ND1 recombinant proteins also provides a platform for investigating its biochemical properties, interactions, and potential as a therapeutic target. In summary, the study of MT-ND1 recombinant protein is critical for advancing our understanding of mitochondrial bioenergetics and developing innovative strategies to address mitochondrial diseases.
