Analytical Data
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Gene name
Tulp1
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简介
The Tulp1 protein is critical for normal development and function of photoreceptor synapses, affecting long-term survival. It interacts with cytoskeletal proteins and may be involved in protein transport within photoreceptor cells. Tulp1 Protein, Human (His) is the recombinant human-derived Tulp1 protein, expressed by E. coli , with N-His labeled tag.
- Application
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Alternative Names
Tubby-related protein 1; Tubby-like protein 1; TULP1; TUBL1; LCA15; RP14;
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Species
Human
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Source
E. coli
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Tag
N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00294-2
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Expression Region
M1-E489
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Protein Length
Full Length of Isoform-2
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Molecular Weight
55.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TULP1 (tubby-like protein 1) is a member of the tubby-like protein family and plays a crucial role in the development and function of the photoreceptor cells in the retina. Mutations in the TULP1 gene have been associated with various forms of retinal degeneration, including retinitis pigmentosa, leading to vision loss and blindness. Due to its significant role in photoreceptor cell biology, TULP1 has become a focal point of research in the field of retinal diseases. Recombination and expression of TULP1 protein in various model systems allow researchers to investigate its biological functions, interaction partners, and the mechanisms by which it influences photoreceptor development and maintenance. Understanding the structure and function of TULP1 is essential for developing potential therapeutic strategies to ameliorate vision loss caused by TULP1 mutations. Moreover, TULP1's involvement in cellular processes such as ciliary trafficking and membrane receptor signaling highlights its importance beyond just retinal health, opening avenues for research into broader cellular mechanisms and potential applications in regenerative medicine. Given the pressing need for effective treatments for retinal degenerative diseases, studies focused on TULP1 recombinant protein hold promise for uncovering novel insights and therapeutic targets that can ultimately benefit patients affected by these debilitating conditions.
