Analytical Data
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Gene name
TENM2
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简介
TENM2 Protein plays a crucial role in neural development, facilitating proper connectivity in the nervous system by promoting filopodia formation and enlarged growth cones in neurons. It functions as a ligand for the ADGRL1 receptor, mediating axon guidance and heterophilic cell-cell adhesion. TENM2 Protein, Human (HEK293, His) is the recombinant human-derived TENM2 protein, expressed by HEK293 , with N-His labeled tag.
- Application
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Alternative Names
Teneurin-2; Ten-2; Tenascin-M2; Ten-m2; KIAA1127; ODZ2; TNM2
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Species
Human
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Source
HEK293
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Tag
N-8*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NT68-1
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Expression Region
G401-N841
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Protein Length
Partial
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Molecular Weight
55-65 kDa & 38-43 kDa & 25-30 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TENM2, a member of the Tenascin family of proteins, plays a critical role in the development and functioning of the nervous system. Its unique extracellular matrix properties contribute to cell adhesion, signaling, and the organization of neural networks. Recent studies have highlighted the importance of TENM2 in various neurological processes and its potential involvement in neurodevelopmental disorders and neurodegenerative diseases, such as schizophrenia and Alzheimer's disease. The recombinant expression of TENM2 protein facilitates the exploration of its biochemical properties and functional mechanisms. Researchers are particularly interested in how TENM2 interacts with other proteins and its role in synaptic plasticity and neuronal connectivity. Understanding the structure and function of TENM2 at the molecular level may provide insights into its therapeutic potential and role in disease pathogenesis. As a result, the generation of TENM2 recombinant protein is pivotal for advancing both basic research and potential clinical applications, allowing scientists to elucidate its biological functions and evaluate its potential as a biomarker or therapeutic target in various neurological conditions.
