Analytical Data
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Gene name
LMNB1
- Application
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Alternative Names
LMN; LMN2; LMNB
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P20700
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Expression Region
Ser52~Gly233
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Molecular Weight
30&26&25kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
LMNB1, or Lamin B1, is a vital component of the nuclear lamina, a network of filaments located beneath the inner nuclear membrane, playing critical roles in maintaining nuclear structure and regulating various cellular processes, including gene expression, DNA replication, and cell division. Mutations in the LMNB1 gene have been associated with a range of diseases, particularly those affecting the nervous system such as leukodystrophy and muscular dystrophies, highlighting its essential role in cellular integrity and function. Recent studies have focused on the recombinant expression of LMNB1 protein to facilitate a deeper understanding of its structure-function relationship and its involvement in pathological conditions. By producing LMNB1 as a recombinant protein, researchers can conduct detailed biochemical and biophysical analyses, which may reveal how alterations in its structure lead to disease states. This research also aims to explore potential therapeutic targets by identifying small molecules or peptides that can modulate LMNB1 activity. Moreover, recombinant LMNB1 can be used in cell biology studies to investigate its interactions with other nuclear proteins and its role in nuclear transport mechanisms. As the understanding of LMNB1’s functions expands, it may provide insights into broader implications for nuclear envelope biology and its links to human diseases, thereby paving the way for innovative strategies for diagnosis and treatment.
