Analytical Data
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Gene name
KIF5B
- Application
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Alternative Names
KNS1; UKHC; KINH; Conventional kinesin heavy chain; Ubiquitous kinesin heavy chain; Kinesin-1 heavy chain
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q2PQA9
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Expression Region
Ile9~Lys226
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Molecular Weight
32kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KIF5B, a member of the kinesin superfamily of motor proteins, plays a critical role in intracellular transport, specifically in the anterograde movement of organelles and vesicles along microtubules. This protein is composed of a motor domain that facilitates binding to microtubules and a cargo-binding domain that interacts with various cellular components, thereby influencing cellular dynamics. Research into KIF5B has gained importance due to its implications in various biological processes, including neuronal function and development, as well as its potential involvement in certain diseases, such as cancer. Aberrant expression and mutations in KIF5B have been linked to alterations in cellular transport mechanisms, which can ultimately affect cell proliferation and survival. The study of KIF5B recombinant proteins provides insights into its structure-function relationship and the molecular mechanisms by which it mediates intracellular transport. Moreover, recombinant KIF5B proteins can serve as valuable tools in drug delivery systems and therapeutic interventions, particularly in targeting diseases characterized by disrupted intracellular transport. Understanding KIF5B's precise interactions and pathways may illuminate novel therapeutic avenues for treating various disorders associated with mitotic and neuronal dysfunction. Thus, the continued exploration of KIF5B through recombinant protein studies is critical for advancing our knowledge of cellular transport processes and their implications in health and disease.
