Analytical Data
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基因名
KATNB1
- Application
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别名
KAT; Katanin p80 WD40-Containing Subunit B1
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BVA0
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表达区间
Gln377~Asp655
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分子量
37kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KATNB1 (Katanin p60 ATPase-containing subunit B1) is a crucial component of the katanin protein complex, which plays a significant role in microtubule severing and organization within eukaryotic cells. Its function is essential for various cellular processes, including cell division, differentiation, and response to cellular stress. Research on KATNB1 has gained attention due to its potential implications in understanding diseases characterized by cytoskeletal abnormalities, such as neurodegenerative disorders, cancer, and developmental defects. As an ATPase, KATNB1 exhibits motor protein activity that regulates the dynamics of microtubule networks, influencing cellular architecture and signaling pathways. Advances in recombinant protein technology have enabled the production of KATNB1 in vitro, allowing for detailed biochemical and structural studies. This research aims to elucidate the mechanistic roles of KATNB1 in microtubule dynamics and explore its potential as a therapeutic target. Understanding KATNB1's interactions with other cytoskeletal components and regulatory proteins could provide insights into the molecular basis of cytoskeletal-related diseases and pave the way for novel therapeutic strategies.
