Analytical Data
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基因名
PCDH15
- Application
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别名
USH1F; DFNB23; CDHR15; Deafness,Autosomal Recessive 23; Cadherin-Related Family Member 15
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种属
Mouse
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99PJ1
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表达区间
Pro45~Phe270
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分子量
34kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCDH15 (protocadherin 15) is a member of the protocadherin family, which plays crucial roles in cell adhesion and signaling, particularly in the auditory and visual systems. Mutations in the PCDH15 gene are linked to various forms of hereditary hearing loss and other sensory deficits, highlighting its significance in sensory cell function and development. Researchers have focused on generating recombinant PCDH15 proteins to elucidate their structural properties and functional mechanisms, providing insights into how these proteins mediate cell-cell interactions and contribute to the integrity of sensory tissues. Understanding the dynamics of PCDH15 through recombinant forms can pave the way for developing therapeutic interventions for genetic disorders associated with its malfunction. By studying the protein's interactions with other cellular components and its role in the formation of sensory synapses, scientists aim to uncover new pathways involved in auditory and visual processing, ultimately enhancing our knowledge of sensory biology and potential treatment strategies for related disorders. This research is pivotal for both basic science and clinical applications, as it informs approaches to restore or enhance sensory function in patients affected by PCDH15 mutations.
