Analytical Data
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基因名
PCDHa8
- Application
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种属
Rat
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q767I4
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表达区间
Gln30~Thr260
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分子量
30kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PCDHa8, a member of the Pcdh (protocadherin) family, is a type of cell adhesion molecule known for its role in the central nervous system, particularly in neuronal development and synaptic function. The Pcdh family consists of dozens of members that contribute to the establishment and maintenance of specific neural circuits, influencing various processes such as axon guidance, synaptogenesis, and synaptic plasticity. Research has shown that PCDHa8 is involved in mediating cell-cell interactions critical for proper neuronal connectivity. Abnormalities in protocadherin expression have been implicated in neurological disorders, including schizophrenia and autism spectrum disorders, underscoring the importance of understanding their functions. The study of PCDHa8 recombinant protein aims to elucidate its structural properties, binding mechanisms, and biological roles, providing insight into how it contributes to neuronal network formation and function. By focusing on PCDHa8, researchers hope to advance knowledge in neurobiology and potentially identify novel therapeutic targets for treating related neurological conditions. Furthermore, characterizing this protein's interactions and pathways could pave the way for innovative strategies to manipulate synaptic formation and repair, ultimately contributing to our understanding of brain function and the treatment of neurodevelopmental disorders.
