Analytical Data
-
Gene name
PTK2
- Application
-
Alternative Names
Focal adhesion kinase-related nonkinase ;FRNK ;p41/p43FRNKProtein-tyrosine kinase 2p125FAKpp125FAK
-
Species
Chicken
-
Source
E. coli
-
Tag
N- GST
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q00944
-
Expression Region
376-683aa
-
Molecular Weight
62.3 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PTK2 (also known as FAK, focal adhesion kinase) is a non-receptor tyrosine kinase that plays a pivotal role in cellular processes such as adhesion, migration, and survival. Research into PTK2 has gained significant attention due to its involvement in various pathological conditions, including cancer progression, metastasis, and wound healing. The overexpression and hyperactivation of PTK2 have been linked to tumorigenesis, making it a target for therapeutic interventions. In cancer cells, PTK2 modulates signaling pathways that promote cell proliferation and invasiveness, underscoring its role in enhancing malignancy. Additionally, PTK2 interacts with several proteins within focal adhesions to regulate cellular responses to the extracellular matrix. The study of PTK2 and its signaling networks is critical for understanding not only cancer biology but also broader aspects of cell physiology. Recent advancements in recombinant protein technology have enabled the production of PTK2 and its active domains, facilitating detailed biophysical and biochemical characterization. Through these investigations, researchers aim to elucidate the specific mechanisms by which PTK2 influences cellular behavior and to explore its potential as a biomarker and therapeutic target. Understanding the structure-function relationship of PTK2 is essential for developing targeted therapies that could inhibit its activity and, consequently, impede cancer cell growth and spread.
