Analytical Data
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Gene name
MYOT
- Application
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Alternative Names
LGMD1; LGMD1A; TTID; Myotolin; Myofibrillar Titin-Like Protein; TiTin Immunoglobulin Domain; Limb-Girdle Muscular Dystrophy 1A; 57 kDa cytoskeletal protein
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Species
Mouse
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9JIF9
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Expression Region
Arg6~Leu188
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Molecular Weight
29kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MYOT, or myotilin, is a protein encoded by the MYOT gene, primarily expressed in skeletal muscle and cardiac tissues. It plays a significant role in muscle structure and function, and mutations or dysregulation of MYOT have been implicated in various myopathies, particularly myofibrillar myopathy. Research on MYOT recombinant proteins has garnered attention due to their potential as therapeutic agents and tools for understanding muscle biology. The study of MYOT is crucial in the context of muscle regeneration and repair mechanisms, as well as in developing strategies for treating muscle diseases. Investigating the properties and functions of MYOT recombinant proteins not only helps unveil the underlying molecular mechanisms of muscle disorders but also contributes to the discovery of biomarkers for early diagnosis and the evaluation of therapeutic interventions. By producing and analyzing MYOT in a recombinant form, researchers can explore its interactions with other muscle-related proteins and assess its role in muscle integrity and function, paving the way for innovative treatments targeting myopathies and enhancing our understanding of muscle physiology.
