Analytical Data
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Gene name
PAR4
- Application
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Alternative Names
F2RL3; PAR-4; Coagulation Factor II Thrombin Receptor-Like 3; Coagulation factor II receptor-like 3
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Species
Human
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Source
E. coli
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Tag
N- His & GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96RI0
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Expression Region
Gly48~Gln385
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Molecular Weight
66kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PAR4 (prostate apoptosis response-4) is a tumor suppressor protein that plays a crucial role in regulating apoptosis and cell survival, thus being of significant interest in cancer research. Initially identified for its expression in prostate tissues, PAR4 has been found to be involved in various cellular processes, including cell cycle regulation and response to stress. Its unique feature is the ability to induce tumor cell death through a selective apoptosis pathway, making it a potential target for therapeutic interventions in cancer treatment, particularly in prostate cancer. Recent studies have highlighted the importance of PAR4 in enhancing the sensitivity of cancer cells to chemotherapy and radiation, suggesting that modulating its activity could improve treatment outcomes. Furthermore, research has explored the mechanisms by which PAR4 functions, including its interactions with other cellular proteins and its role in various signaling pathways. Given the rising incidence of prostate and other cancers, understanding the function and mechanisms of PAR4 reconstituted proteins could offer new insights into cancer biology and lead to the development of novel therapeutic strategies. The investigation of PAR4 may not only shed light on potential cancer treatments but also enhance the understanding of apoptosis and the complexities of tumor biology, thereby contributing significantly to the field of oncology.
