Cat: IPD-X38233

Recombinant Human PAR4 Protein,His & GST

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Analytical Data

  • 基因名

    PAR4

  • Application

    SPRMSTBLIITCELISA细胞实验药物筛选

  • 别名

    F2RL3; PAR-4; Coagulation Factor II Thrombin Receptor-Like 3; Coagulation factor II receptor-like 3

  • 种属

    Human

  • 表达系统

    E. coli

  • 标签

    N- His & GST

  • 纯度

    Greater than 90% as determined by SDS-PAGE.

  • 蛋白编号

    Q96RI0

  • 表达区间

    Gly48~Gln385

  • 分子量

    66kDa

  • 内毒素

    < 1.0 EU per μg protein as determined by the LAL method.

  • 性状

    Freeze-dried powder

  • 缓冲液

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • 复溶方法

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • 个性化定制

    点位突变 标签定制 buffer定制 全长蛋白定制

  • 稳定性测试

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • 保存条件 & 期限

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • 运输条件

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

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Protein Description

PAR4 (prostate apoptosis response-4) is a tumor suppressor protein that plays a crucial role in regulating apoptosis and cell survival, thus being of significant interest in cancer research. Initially identified for its expression in prostate tissues, PAR4 has been found to be involved in various cellular processes, including cell cycle regulation and response to stress. Its unique feature is the ability to induce tumor cell death through a selective apoptosis pathway, making it a potential target for therapeutic interventions in cancer treatment, particularly in prostate cancer. Recent studies have highlighted the importance of PAR4 in enhancing the sensitivity of cancer cells to chemotherapy and radiation, suggesting that modulating its activity could improve treatment outcomes. Furthermore, research has explored the mechanisms by which PAR4 functions, including its interactions with other cellular proteins and its role in various signaling pathways. Given the rising incidence of prostate and other cancers, understanding the function and mechanisms of PAR4 reconstituted proteins could offer new insights into cancer biology and lead to the development of novel therapeutic strategies. The investigation of PAR4 may not only shed light on potential cancer treatments but also enhance the understanding of apoptosis and the complexities of tumor biology, thereby contributing significantly to the field of oncology.

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IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
IPODIX North America (HQ)
Proteintech Group, Inc
5500 Pearl Street, Suite 400
Rosemont, IL 60018, USA
1-888-478-4522
proteintech@ptglab.com
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