Analytical Data
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Gene name
TGFa
- Application
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Alternative Names
ETGF; TGF-A; Protransforming Growth Factor alpha; EGF-Like TGF
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P01135
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Expression Region
Glu24~Ala98
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Molecular Weight
13kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Transforming Growth Factor-alpha (TGFa) is a member of the epidermal growth factor (EGF) family, playing a pivotal role in various biological processes, including cell proliferation, differentiation, and survival. Initially identified as a potent mitogen for epithelial cells, TGFa has garnered significant attention due to its involvement in normal tissue homeostasis and its dysregulation in several diseases, particularly cancers. Research has shown that TGFa participates in autocrine and paracrine signaling pathways, influencing cellular behaviors and contributing to tumor progression and metastasis. The development of recombinant TGFa proteins has been crucial for elucidating its functional mechanisms and biological roles. Such recombinant proteins provide a tool for investigating TGFa's effects on cell signaling pathways and its interactions with specific receptors. Moreover, TGFa is being explored as a potential therapeutic target in oncology, offering insights into novel treatment strategies for malignancies characterized by its overexpression. The ongoing study of TGFa, particularly its recombinant forms, aims to clarify its role in disease processes and enhance the understanding of its potential in therapeutic applications, representing an important avenue in cancer research and regenerative medicine.
