Analytical Data
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基因名
TGFa
- Application
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别名
ETGF; TGF-A; Protransforming Growth Factor alpha; EGF-Like TGF
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01135
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表达区间
Glu24~Ala98
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分子量
13kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Transforming Growth Factor-alpha (TGFa) is a member of the epidermal growth factor (EGF) family, playing a pivotal role in various biological processes, including cell proliferation, differentiation, and survival. Initially identified as a potent mitogen for epithelial cells, TGFa has garnered significant attention due to its involvement in normal tissue homeostasis and its dysregulation in several diseases, particularly cancers. Research has shown that TGFa participates in autocrine and paracrine signaling pathways, influencing cellular behaviors and contributing to tumor progression and metastasis. The development of recombinant TGFa proteins has been crucial for elucidating its functional mechanisms and biological roles. Such recombinant proteins provide a tool for investigating TGFa's effects on cell signaling pathways and its interactions with specific receptors. Moreover, TGFa is being explored as a potential therapeutic target in oncology, offering insights into novel treatment strategies for malignancies characterized by its overexpression. The ongoing study of TGFa, particularly its recombinant forms, aims to clarify its role in disease processes and enhance the understanding of its potential in therapeutic applications, representing an important avenue in cancer research and regenerative medicine.
