Analytical Data
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Gene name
PFDN2
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简介
The PFDN2 protein selectively binds to the cytoplasmic chaperone protein (c-CPN) and directs the protein for targeted transfer. It also interacts with nascent peptides and actively promotes correct folding in complex cellular environments. PFDN2 Protein, Human (His) is the recombinant human-derived PFDN2 protein, expressed by E. coli , with N-6*His labeled tag.
- Application
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Alternative Names
Prefoldin Subunit 2; PFDN2; PFD2
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Species
Human
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Source
E. coli
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Tag
N-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UHV9
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Expression Region
M1-S154
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Protein Length
Full Length
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Molecular Weight
19 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PFDN2 (Prefoldin-2) is a chaperone protein involved in the assembly and folding of nascent polypeptides. It plays a critical role in the protein maturation process by aiding in the proper folding of newly synthesized proteins, thereby preventing misfolding and aggregation. Research has revealed that PFDN2 is essential in various cellular processes, including stress response, development, and differentiation. It has been implicated in several diseases, including cancer and neurodegenerative disorders, where its dysregulation can lead to protein misfolding and aggregation. The study of recombinant PFDN2 protein serves to elucidate its structural and functional properties, allowing researchers to better understand its mechanism of action and role in cellular homeostasis. By producing PFDN2 in a recombinant system, scientists can obtain large quantities of the protein for biochemical analyses and functional assays. This research is vital not only for exploring the fundamental biology of chaperone proteins but also for developing potential therapeutic strategies targeting PFDN2 in disease contexts. Understanding the interactions of PFDN2 with substrate proteins can provide insights into protein folding pathways, with implications for improving protein stability in therapeutic protein production and designing novel intervention strategies for diseases associated with protein misfolding.
