Analytical Data
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Gene name
PCDH1
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简介
The PCDH1 protein has been implicated in cell-cell interactions and adhesion, suggesting a role in important cellular processes. Its involvement in cell adhesion highlights its importance in forming and maintaining cell junctions. PCDH1 Protein, Human (HEK293, His) is the recombinant human-derived PCDH1 protein, expressed by HEK293 , with C-6*His labeled tag.
- Application
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Alternative Names
Protocadherin-1; Cadherin-Like Protein 1; Protocadherin-42; PC42; PCDH1
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Species
Human
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Source
HEK293
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Tag
C-6*His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q08174
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Expression Region
T58-N852
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AA Sequence
TRVVYKVPEEQPPNTLIGSLAADYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIAGDPEYERSKQRGN
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Protein Length
Extracellular Domain
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Molecular Weight
120.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PCDH1, or protocadherin 1, is a member of the cadherin superfamily, which plays crucial roles in cell adhesion and signaling pathways. It is primarily expressed in the nervous system and has been implicated in various neurological processes, including synaptic function and neuronal development. Research indicates that PCDH1 may be involved in the regulation of neural circuit formation and maintenance, making it vital for proper brain function. Aberrations in PCDH1 expression or function have been associated with several neurodevelopmental disorders, such as autism spectrum disorders and schizophrenia. To further explore its biological functions and therapeutic potential, scientists have focused on the production of recombinant PCDH1 proteins. These recombinant proteins enable detailed studies of PCDH1’s structural characteristics, interactions with other cellular components, and downstream signaling pathways. The development of PCDH1-based assays and models could provide deeper insights into its role in neurobiology and disease, potentially paving the way for novel therapeutic strategies targeting PCDH1-related pathways. Understanding PCDH1's mechanisms may ultimately contribute to the development of interventions for neurodevelopmental and psychiatric disorders, highlighting its significance in both basic research and clinical applications.
