Analytical Data
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Gene name
TWSG1
- Application
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Alternative Names
TSG
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q9GZX9
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Expression Region
Cys26~Phe223
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Molecular Weight
24kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TWSG1 (Twisted Gastrulation Protein 1) is a secreted extracellular matrix protein that plays a vital role in embryonic development and tissue patterning by modulating the activity of bone morphogenetic proteins (BMPs). Its significance in developmental biology stems from its ability to influence cellular processes such as proliferation, differentiation, and apoptosis, thereby impacting organogenesis and morphogenesis. Dysregulation of TWSG1 has been linked to various developmental disorders and diseases, including certain forms of cancer. Researchers have been focused on characterizing the structure and function of TWSG1 through recombinant protein studies, which aim to elucidate its precise mechanisms of action in BMP signaling pathways. The exploration of TWSG1 as a therapeutic target is also gaining traction, as understanding its interactions could pave the way for novel interventions in conditions stemming from aberrant BMP signaling. Overall, the investigation of TWSG1 recombinant protein not only enhances our comprehension of fundamental developmental processes but also holds potential implications for clinical applications in regenerative medicine and oncology.
