Analytical Data
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Gene name
SLC35D2
- Application
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Alternative Names
Fringe connection; HFRC 1; Hfrc; HFRC1; Homolog of Fringe connection protein 1; MGC117215; MGC142139; Nucleotide sugar transporter UGTrel8; S35D2_HUMAN; SLC35D2; Solute carrier family 35 member D2; SQV 7L; SQV7-like protein; SQV7L; UDP N acetylglucosamine transporter; UDP-galactose transporter-related protein 8; UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; UGTrel 8; UGTrel8
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q76EJ3
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Expression Region
1-249 aa
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AA Sequence
MTAGGQAEAEGAGGEPGAARLPSRVARLLSALFYGTCSFLIVLVNKALLTTYGFPSPIFLGIGQMAATIMILYVSKLNKIIHFPDFDKKIPVKLFPLPLLYVGNHISGLSSTSKLSLPMFTVLRKFTIPLTLLLETIILGKQYSLNIILSVFAIILGAFIAAGFLLMYSTVLCSYYNSALTTAVVGAIKNVSVAYIGILIGGDYIFSLLNFVGLNICMAGGLRYSFLTLSSQLKPKPVGEENICLDLKS
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Molecular Weight
53.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SLC35D2 is a member of the solute carrier (SLC) family that is primarily responsible for the transport of nucleotide sugars across cellular membranes. Research into SLC35D2 has gained significant attention due to its potential role in various biological processes, including glycosylation, which is crucial for protein folding, stability, and cell signaling. Dysregulation of SLC35D2 has been implicated in several diseases, including cancers and congenital disorders. The study of recombinant SLC35D2 protein is important for understanding its structure-function relationship, as well as its mechanisms of action in cellular contexts. By producing and characterizing the recombinant form of SLC35D2, researchers can investigate its transport properties, substrate specificity, and interaction with other cellular components. This research can provide insights into the molecular basis of diseases related to glycosylation defects and pave the way for the development of targeted therapeutic strategies. Additionally, understanding SLC35D2's role in nucleotide sugar transport can have broader implications in biotechnology, particularly in the engineering of glycosylation pathways for enhanced production of biopharmaceuticals. Thus, the exploration of SLC35D2 recombinant protein serves as a critical area of investigation within cellular biology and translational medicine.
