Analytical Data
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Gene name
SLC6A2
- Application
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Alternative Names
Slc6a2; SLC6A5; Sodium dependent noradrenaline transporter
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Species
Human
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Source
E. coli
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Tag
His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P23975
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Expression Region
1-617aa
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AA Sequence
MEKARPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCPLNGNHTGYDEECEKASSTQYFWYRKTLNISPSLQENGGVQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINSFTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYSEMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAILTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQGQLVTKDYPAYALAVIGLLVASSTMCIPLAALGTFVQRRLKRGDADPVA
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Molecular Weight
69,3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Identification
Protein Description
SLC6A20, a member of the solute carrier family, encodes a sodium-dependent amino acid transporter primarily involved in the reabsorption of proline and other amino acids in the renal tubules and intestines. Research into SLC6A20 has garnered attention due to its critical role in amino acid transport and potential implications in various physiological processes and pathologies. Mutations or dysregulation of SLC6A20 have been linked to disorders such as Hartnup disorder, characterized by the impaired transport of essential amino acids, leading to clinical manifestations like deficiency in essential amino acids and associated symptoms. Moreover, the transporter is believed to play a role in the uptake of proline in the context of kidney function and gastrointestinal health. The study of SLC6A20 at the protein level, particularly through the production of recombinant SLC6A20 protein, allows researchers to investigate its functional properties, transport kinetics, and interaction with potential substrates and inhibitors. This research is crucial for understanding the transport mechanisms mediated by SLC6A20, as well as for identifying therapeutic targets for disorders related to amino acid transport. Additionally, recombinant SLC6A20 proteins serve as valuable tools in drug discovery, enabling the exploration of compounds that may enhance or inhibit its function, thereby contributing to the development of novel therapeutic strategies for metabolic disorders and enhancing our understanding of amino acid homeostasis in human health.
