Analytical Data
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Gene name
GJA3
- Application
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Alternative Names
GJA3; Gap junction alpha-3 protein; Connexin-46; Cx46
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9Y6H8
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Expression Region
1-435aa
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AA Sequence
MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEDVWGDEQSDFTCNTQQPGCENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRMEEKKKEREEEEQLKRESPSPKEPPQDNPSSRDDRGRVRMAGALLRTYVFNIIFKTLFEVGFIAGQYFLYGFELKPLYRCDRWPCPNTVDCFISRPTEKTIFIIFMLAVACASLLLNMLEIYHLGWKKLKQGVTSRLGPDASEAPLGTADPPPLPPSSRPPAVAIGFPPYYAHTAAPLGQARAVGYPGAPPPAADFKLLALTEARGKGQSAKLYNGHHHLLMTEQNWANQAAERQPPALKAYPAASTPAAPSPVGSSSPPLAHEAEAGAAPLLLDGSGSSLEGSALAGTPEEEEQAVTTAAQMHQPPLPLGDPGRASKASRASSGRARPEDLAI
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Molecular Weight
47.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GJA3, also known as Gap Junction Protein Alpha 3, is a member of the connexin family and plays a crucial role in intercellular communication by forming gap junctions that facilitate the direct transfer of ions and small molecules between adjacent cells. Research into GJA3 has gained prominence due to its significant involvement in various physiological processes, including embryonic development and cellular homeostasis, as well as its implications in several pathologies. Mutations in the GJA3 gene have been linked to congenital cataracts and other ocular disorders, highlighting its importance in eye health. Furthermore, aberrant expression of GJA3 has been associated with certain cancers and other diseases, suggesting a potential role in tumorigenesis and disease progression. Understanding the structure, function, and regulatory mechanisms of GJA3 through recombinant protein studies is essential for unraveling its biological significance and therapeutic potential. These studies not only aid in elucidating the molecular basis of related diseases but also offer insights into targeted treatment strategies, making GJA3 a focal point of interest in molecular biology, genetics, and clinical research. The development of recombinant GJA3 provides a powerful tool for investigating its functional properties, interactions, and clinical relevance, paving the way for new interventions and therapeutic avenues in precision medicine.
