Analytical Data
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Gene name
GIN1
- Application
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Alternative Names
GIN1; TGIN1; ZH2C2Gypsy retrotransposon integrase-like protein 1; GIN-1; Ty3/Gypsy integrase 1; Zinc finger H2C2 domain-containing protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NXP7
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Expression Region
1-522aa
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AA Sequence
MVRSGKNGDL HLKQIAYYKR TGEYHSTTLP SERSGIRRAA KKFVFKEKKL FYVGKDRKQN RLVIVSEEEK KKVLRECHEN DSGAHHGISR TLTLVESNYY WTSVTNDVKQ WVYACQHCQV AKNTVIVAPK QHLLKVENPW SLVTVDLMGP FHTSNRSHVY AIIMTDLFTK WIVILPLCDV SASEVSKAII NIFFLYGPPQ KIIMDQRDEF IQQINIELYR LFGIKQIVIS HTSGTVNPTE STPNTIKAFL SKHCADHPNN WDDHLSAVSF AFNVTHLEPT KNTPYFQMFS RNPYMPETSD SLHEVDGDNT SMFAKILDAI KEADKIMENK TTSLGQMENN NLDELNKSKI IVKKKPKQLN PFHLKVGHEV LRQRKNWWKD GRFQSEWVGP CVIDYITESG CAVLRDNTGV RLKRPIKMSH LKPYIRESSE QESLYLLQGS VVADHDYIGL PEIPIGAYQA NILVEDATIG IVDNELLTSS KDRELLEYRN TKISPLIDDH SSLEKQTFSL LDSSNQVLEY LS
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Molecular Weight
59.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GIN1 (Generalized inositol-1) is a significant protein that plays a crucial role in various cellular processes, particularly in the context of cell signaling and cytoskeletal dynamics. Initially identified in studies investigating cell growth and division, GIN1 has garnered attention for its involvement in the regulation of actin filament organization and the modulation of cellular responses to external stimuli. Research indicates that GIN1 functions as a scaffold protein, facilitating the assembly of signaling complexes that govern essential pathways, including those linked to cancer progression and metastasis. Recent studies highlight its potential as a biomarker for certain cancers, as altered levels of GIN1 expression have been correlated with tumorigenesis. Additionally, the protein's interaction with phosphoinositides suggests a pivotal role in membrane trafficking and endocytosis, further illustrating its importance in cellular homeostasis. By exploring the biochemical properties and functional mechanisms of GIN1, researchers aim to develop targeted therapeutic strategies that could mitigate its aberrant activities in pathological contexts, particularly in tumor biology. The ongoing investigation of GIN1's structure-function relationships also opens avenues for innovative drug design, making it an attractive candidate for future translational research in oncology and cell biology.
